减少超加工食品摄入可能改善抑郁症症状

加州大学旧金山分校发表于《JAMA精神病学》的一项初步研究表明，患有抑郁症的人通过减少超加工食品摄入超过85%，其抑郁症症状在三个不同的测量指标上出现了中等至显著的改善1。该研究涉及20名参与者，平均年龄44岁，其中70%为女性，所有人的身体质量指数较高且至少存在一种代谢紊乱1。

在为期四周的对照试验中，一组参与者保持常规饮食，另一组改为低超加工食品饮食，四周后两组进行交换1。焦虑评分在干预期间也显示出适度改善1。

研究人员推测这种改善可能与减少肠道损伤和慢性炎症有关1。基于这些初步结果，研究小组计划进行更大规模的试验进一步验证这一发现，第二阶段的参与者招募预计于2028年开始1。

Researchers at the University of California, San Francisco have published preliminary findings indicating that individuals with depression who cut their ultra-processed food consumption by more than 85% demonstrated moderate to significant improvements across three separate depression measurement scales.1 The study, published in JAMA Psychiatry on September 23, 2026, enrolled 20 participants with an average age of 44, of whom 70% were women.1 All participants had elevated body mass index and at least one metabolic disorder.1

The research employed a crossover design in which one group maintained their regular diet for four weeks while the other group switched to a low ultra-processed food diet during the same period, after which the groups exchanged approaches.1 Beyond depression symptom reduction, participants also experienced modest improvements in anxiety scores.1 The investigators hypothesize that the observed improvements may be linked to decreased intestinal damage and reduced chronic inflammation.1 Plans are underway for a larger-scale trial, with recruitment for the second phase expected to begin in 2028.1