一项针对老年人的试点研究表明，连续三个月每天食用蓝莓可能会影响抑郁症状，这一效果可能与肠道微生物的变化有关。1该研究由Hebrew SeniorLife Hinda and Arthur Marcus Institute for Aging Research开展，已发表于《营养、健康和衰老杂志》。1
研究共纳入18名65岁及以上、身体不活跃且有轻度抑郁症状的参与者，其中蓝莓组10人（平均年龄71±4岁），安慰剂组8人（平均年龄75±6岁）。1干预组参与者每天消费48克蓝莓粉，相当于约两杯新鲜浆果。1结果显示，蓝莓组的抑郁症状出现了更明显和更一致的减少，但与安慰剂组相比这一改善在统计学上并不显著。1
研究人员发现，蓝莓组参与者的肠道微生物酶基因发生了变化，包括与神经递质GABA生成相关的EC 3.6.3.31多胺转运ATP酶丰度的改变。1首席作者Courtney L. Millar表示："蓝莓中的纤维和花青素有可能改变老年人肠道微生物群和与抑郁症相关的代谢产物。"1这些发现提示可能存在肠-脑连接机制。
A pilot study suggests that older adults consuming blueberries daily for three months experienced more pronounced reductions in depressive symptoms, accompanied by changes in gut microbial enzyme genes that point to a potential gut-brain connection.1 However, the mood improvement in the blueberry group compared to the placebo group was not statistically significant.1
The research involved 18 participants aged 65 and older who were physically inactive and exhibited mild depressive symptoms.1 Those assigned to the blueberry intervention consumed 48 grams of blueberry powder daily—equivalent to approximately two cups of fresh berries—over the three-month period.1 The placebo group consisted of eight participants with a mean age of 75±6 years, while the blueberry group included ten participants with a mean age of 71±4 years.1
Notably, the blueberry group demonstrated statistically significant changes in the abundance of multiple gut microbial enzymes, including EC 3.6.3.31 polyamine transport ATPase, which participates in the generation of the neurotransmitter GABA.1 According to lead author Courtney L. Millar, "the fiber and anthocyanins in blueberries have the potential to alter the gut microbiota and metabolites associated with depression in older adults."1 The findings were published in the Journal of Nutrition, Health and Aging on October 18, 2026.1
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