英国利物浦大学领导的一项为期104周的随机对照试验SWITCH发现，含有非营养性甜味剂的饮食软饮料在长期体重管理中的效果与饮用清水基本相当 1。该试验涉及493名超重或肥胖成年人 1。
在体重减轻方面，饮用含阿斯巴甜、安赛蜜或三氯蔗糖等甜味剂饮料的参与者平均减重4.8千克，而饮用水的对照组平均减重3.7千克，两组间未见显著差异 1。研究还检测了代谢指标改善情况，包括血压和胆固醇水平，未发现有临床意义的组间差异 1。试验证实，在所用甜味剂摄入量均在欧洲食品安全局安全阈值范围内的前提下，这些物质并未干扰食欲调节或造成长期代谢伤害 1。相关成果已发表在《英国营养学杂志》上 1。
A large-scale randomized controlled trial conducted by researchers at the University of Liverpool has found that diet soft drinks sweetened with non-nutritive sweeteners perform comparably to water for long-term weight management.1 The SWITCH study, which ran for 104 weeks and involved 493 overweight or obese adults, demonstrated that participants consuming beverages containing aspartame, acesulfame potassium, or sucralose achieved similar weight loss to those drinking water, with reductions of 4.8 kg and 3.7 kg respectively.1
Beyond weight reduction, the trial revealed no clinically meaningful differences between the two groups in blood pressure or cholesterol levels, and found no evidence that non-nutritive sweeteners interfered with appetite regulation or caused long-term metabolic harm.1 The sweetener intake levels in the study remained within safety thresholds established by the European Food Safety Authority.1 The findings, published in the British Journal of Nutrition in 2026, indicate that diet beverages do not undermine weight loss efforts when consumed as part of a structured weight management program.1
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