佛罗里达大学研究人员发现，广泛使用的关节补充剂葡萄糖胺与认知衰退风险增加存在关联。1根据对2012年至2024年期间1,896名阿尔茨海默病患者和2,750名轻度认知障碍患者健康记录的分析，使用葡萄糖胺的轻度认知障碍患者进展为痴呆的可能性增加25%。1在已诊断阿尔茨海默病的人群中，该补充剂的使用与死亡风险提高25%相关。1
实验室研究为这一关联提供了生物学依据。1科研人员发现，葡萄糖胺这一天然存在的糖相关分子可以穿过血脑屏障，可能通过加强阿尔茨海默病患者大脑中异常的糖蛋白附着过程而造成伤害。1这种过度活跃的代谢途径被认为可能直接导致记忆问题。1
研究人员指出，尽管发现了这一关联，但要确定葡萄糖胺是否直接导致损伤，还需要进行临床试验。1鉴于美国约有700万人患有阿尔茨海默病，1这一发现具有重要的公共卫生意义。相关研究已发表在《自然·代谢》期刊2026年第8卷第6期。1
Researchers at the University of Florida have identified a concerning association between glucosamine use and the advancement of cognitive decline toward dementia. Analysis of health records revealed that glucosamine consumption is connected to a 25% increased likelihood of mild cognitive impairment progressing to dementia 1. Among individuals already diagnosed with Alzheimer's disease, glucosamine use was associated with a 25% higher mortality risk 1.
The study examined health records from 1,896 Alzheimer's disease patients and 2,750 mild cognitive impairment patients collected between 2012 and 2024 1. Laboratory research suggests that this widely used joint supplement may cause harm by enhancing an abnormal process of protein glycosylation in Alzheimer's-affected brains, where excessive metabolic activity directly contributes to memory problems 1. Since glucosamine is a naturally occurring sugar-related molecule capable of crossing the blood-brain barrier, it may play a direct role in this mechanism 1. However, researchers emphasized that clinical trials are necessary to definitively establish whether glucosamine directly causes injury 1.
The findings are particularly significant given that approximately 7 million Americans currently suffer from Alzheimer's disease 1. The research was published in Nature Metabolism, Volume 8, Issue 6, in 2026 1.
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