日本藤田卫生大学研究团队发现，一种源自大豆的天然化合物LPC70能够保护小鼠免受过量食盐摄入的有害影响。1这项研究由该校医学科学研究生院的森晋裕教授和窪田久義博士主持，相关成果已于2026年7月1日发表在《神经化学国际》第197卷。1
在实验中，研究人员向高盐饮食小鼠补充LPC70后观察到显著效果。1血压得到降低，记忆力和社交互动能力均有改善。1相比之下，未获补充的高盐饮食小鼠则表现出社交互动减少和物体识别记忆困难。1
LPC70作为溶血磷脂酰胆碱化合物，其含量占大豆磷脂总量的70%以上。1研究表明该化合物通过选择性调节前列腺素信号通路发挥保护作用。1在肾脏中，LPC70降低了与盐相关高血压相关的COX-2和PGE2受体EP3的表达。1而在前额皮质脑区，LPC70恢复了与脑保护和抗炎信号相关的PGD2受体DP1的表达。1
Researchers at Fujita Health University in Japan have identified a soybean-derived compound called LPC70 that may protect against the harmful effects of high salt intake on the brain and cardiovascular system.1 When administered to mice on high-salt diets, LPC70 supplementation reduced blood pressure, improved memory retention, and enhanced social interaction.1 The compound comprises more than 70 percent of total phospholipid content and appears to work through selective modulation of prostaglandin signaling pathways in distinct tissue locations.1
The protective mechanisms operate differently across the body.1 In the kidneys, LPC70 decreased expression of COX-2 and the PGE2 receptor EP3, which are associated with salt-related hypertension.1 In the prefrontal cortex of the brain, the compound restored expression of the PGD2 receptor DP1, a receptor linked to neuroprotection and anti-inflammatory signaling.1 Mice maintained on high-salt diets exhibited reduced social interactions and difficulty with object recognition memory prior to LPC70 treatment.1
The study was led by Professor Shinyu Mori and Dr. Hisayoshi Kubota from the Department of Regulatory Assessment and Development of Pharmaceuticals and Medical Devices at Fujita Health University's Graduate School of Medical Sciences.1 The findings were published on July 1, 2026, in the International Journal of Neurochemistry, Volume 197.1
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