堪萨斯城酋长队四分卫帕特里克·马霍姆斯在2024年12月14日的一场失利中撕裂前十字韧带，目前已获准参加训练营，计划在第1周对阵丹佛野马队的揭幕战中复出[1]。绿湾包装工队边锋米卡·帕森斯于12月初遭遇膝盖伤势，将以PUP列表身份开始常规赛，预计在第6周左右返场[1]。
旧金山49人队阵容中有多名伤患准备复出。外接手弗雷德·沃纳已从脚踝伤复原，计划在揭幕战亮相[1]；防守端锋尼克·博萨在遭遇膝盖伤势后，预计第1周即可复出[1]；紧锋乔治·基特尔因跟腱断裂，复出时间仍有不确定性，可能在9月11日或之后才能回归[1]。此外，纽约巨人队新秀接手马利克·内伯斯在新秀赛季共获得1204码接球码数后赛季报销，目前已开始参加训练营训练[1]。同队四分卫丹尼尔·琼斯完成率68.0%，传出3101码、19次达阵和8次拦截，随后签下2年8800万美元合同，已复出参加训练[1]。防守锋线球员纳姆迪·马杜布伊克因颈部伤势缺席上赛季大部分时间，现已从PUP列表中恢复[1]。
Several prominent NFL players are set to make their comeback from significant injuries during the 2025 season, with multiple star performers targeting early-season returns to competition. [1] Kansas City Chiefs quarterback Patrick Mahomes, who suffered an ACL tear on December 14, 2024, has been cleared to participate in training camp with the goal of playing in Week 1 against Denver. [1] Dallas Cowboys edge rusher Micah Parsons sustained a knee injury in early December and is expected to begin the regular season on the physically unable to perform (PUP) list, targeting a return by Week 6. [1]
The San Francisco 49ers will welcome back multiple defensive contributors for the upcoming campaign. [1] Fred Warner has recovered from a Week 6 ankle injury and is prepared to play in the season opener, while Nick Bosa, sidelined by a Week 3 knee injury, is projected to return in Week 1. [1] George Kittle faces a more uncertain timeline following an Achilles tendon rupture, with his return date potentially extending to September 11 or beyond. [1] Elsewhere, New York Giants receiver Malik Nabers, who suffered a knee injury in Week 4 that ended his rookie season, recorded 1,204 receiving yards and has begun training camp participation. [1] Ravens defensive tackle Nnamdi Madubuike, who missed most of the previous season due to a neck injury, has recovered and returned from the PUP list. [1]