塔尔图大学研究人员的最新发现表明，多种常见药物会对肠道微生物群造成持久影响。1该研究基于对爱沙尼亚生物样本库2500多名参与者的粪便样本和处方记录分析，发现抗抑郁药、β受体阻滞剂、质子泵抑制剂和苯二氮卓类药物均会导致肠道菌群发生长期改变。1尤其值得注意的是，苯二氮卓类药物对肠道微生物的影响程度与广谱抗生素相当。1这些改变在患者停药数年后仍可被检测到，表明既往的用药史可能与当前肠道微生物的差异密切相关。1
由塔尔图大学基因组学研究所首席作者Dr. Oliver Aasmets和通讯作者Professor Elin Org领导的研究团队，在2025年mSystems期刊第10期发表了相关论文。1
Researchers at the University of Tartu have discovered that several widely prescribed medications produce long-lasting changes to the gut microbiome that can persist years after patients stop taking them.1 The findings, based on analysis of fecal samples and prescription records from over 2,500 participants in the Estonian Biobank, reveal that antidepressants, beta-blockers, proton pump inhibitors, and benzodiazepines all significantly alter intestinal microbial communities.1
Among the medications studied, benzodiazepines demonstrated an effect on gut microbiota comparable to broad-spectrum antibiotics, highlighting the profound impact some common drugs can have on microbial composition.1 The research indicates that past medication use may be substantially linked to current differences in an individual's gut microbiota, suggesting that patients' medication histories should be considered when evaluating their microbial profiles.1
The study was led by Dr. Oliver Aasmets at the University of Tartu's Institute of Genomics, with Professor Elin Org serving as corresponding author. It was published in the journal mSystems in 2025, volume 10 (DOI: 10.1128/msystems.00541-25).1
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