比利时列日大学GIGA神经科学实验室的研究发现，健康中年人频繁的睡眠微觉醒与阿尔茨海默病的遗传风险升高相关1。这项研究以超过500名健康人为样本，分别包括18至31岁的年轻组和50至69岁的年长组1。研究显示，中年参与者中夜间微觉醒频率与阿尔茨海默病遗传风险呈正相关，而年轻人群体中未发现此类关联1。
研究团队认为睡眠测量可能成为识别症状出现前易患阿尔茨海默病人群的早期预警信号1。研究者Puneet Talwar表示，"这些微觉醒因此并非无关紧要，某些特征可能促进参与阿尔茨海默病的蛋白质积累"1。Gilles Vandewalle则指出，"睡眠可能成为早期识别易患者的可及性标志物"1。该研究已于2025年发表在《睡眠》期刊1。
Researchers at the University of Liège's GIGA Neuroscience Laboratory in Belgium have identified a potential early warning sign for Alzheimer's disease in sleep patterns.1 Among more than 500 healthy participants, scientists discovered that frequent nighttime sleep microarousals—brief awakenings during sleep—were positively associated with genetic risk for Alzheimer's in middle-aged adults aged 50 to 69.1 Notably, this correlation was not observed in younger participants aged 18 to 31, suggesting the relationship may emerge at a specific life stage.1
The findings, published in the journal Sleep in 2025, indicate that sleep measurements could serve as an accessible biomarker for identifying individuals at higher risk of developing Alzheimer's before symptoms appear.1 According to researcher Puneet Talwar, these microarousals are not trivial: "certain characteristics may promote protein accumulation involved in Alzheimer's disease."1 Gilles Vandewalle noted that "sleep may become an accessible marker for early identification of those at risk."1 The research underscores the potential of sleep monitoring as a non-invasive tool for risk assessment, particularly relevant given that Belgium is home to more than 220,000 Alzheimer's patients.1
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