德国波恩大学的研究团队实现了一项突破性的细胞年轻化成果。1研究人员将一名80岁捐献者的血液细胞转化为神经干细胞，通过表观遗传学时钟测量发现，这些细胞的分子年龄从80岁降低至不足20岁，逆转了超过60年的细胞衰老过程。12
这项研究采用了直接转录因子重编程技术，将红细胞前体直接转化为神经干细胞，绕过了多能干细胞阶段。1整个年轻化过程历时超过100天，其中在第50天时观察到约60年的分子年龄显著下降。1这一发现为理解细胞衰老机制提供了新的视角，并为开发神经退行性疾病的治疗方法奠定了基础。1
研究成果已发表在《衰老细胞》期刊2026年第25卷第10期。1该项目得到了欧盟地平线2020计划、德国研究基金会以及联邦研究、技术和空间部的资金支持，由波恩大学医院、波恩大学和亚琛工业大学联合完成。1
Researchers at the University of Bonn have successfully transformed blood cells from an 80-year-old donor into neural stem cells with a molecular age below 20, reversing more than six decades of cellular aging 1. The team employed direct transcription factor reprogramming to convert erythroid progenitor cells into neural stem cells, bypassing the pluripotent stem cell stage, with the rejuvenation process spanning over 100 days 1. Within 50 days, the cells demonstrated a significant decline of approximately 60 years in molecular age, as tracked using epigenetic clocks 1.
The findings were published in Aging Cell in October 2026, volume 25, issue 10 1. This research provides a new experimental model for understanding the mechanisms of cellular aging and developing treatments for neurodegenerative diseases 1. The study was supported by funding from the European Union Horizon 2020 program, the German Research Foundation (DFG), and the Federal Ministry of Research, Technology and Space (BMFRT), with collaboration from the University of Bonn Hospital, the University of Bonn, and Aachen University of Technology 1.
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