加州大学伯克利分校的研究人员发现了深度睡眠、生长激素和觉醒之间的脑神经回路，揭示了这一系统的双向调控机制1。这项研究由Yang Dan教授主导，第一作者为博士后研究员Xinlu Ding，已发表在《Cell》期刊2025年第188卷第18期1。研究通过在小鼠模型上植入脑电极记录神经活动，发现睡眠刺激生长激素释放，而生长激素也会向大脑发送信号影响觉醒1。
研究人员Daniel Silverman指出，"睡眠和生长激素形成一个紧密平衡的系统：睡眠不足减少生长激素释放，过量生长激素会促进大脑向觉醒转变"1。Xinlu Ding表示，"生长激素不仅帮助建立肌肉和骨骼、减少脂肪组织，还可能具有认知益处"1。这些发现可能为睡眠障碍和神经退行性疾病的治疗开辟新途径1。该研究获得了Howard Hughes Medical Institute和Pivotal Life Sciences Chancellor's Chair基金的资金支持1。
Researchers at UC Berkeley have identified the brain neural circuit connecting deep sleep, growth hormone release, and wakefulness, revealing a bidirectional relationship within this system 1. The study, published in Cell journal in 2025 (Volume 188, Issue 18, DOI: 10.1016/j.cell.2025.05.039), was led by Professor Yang Dan, with postdoctoral researcher Xinlu Ding as the first author 1. Using implanted electrodes to record neural activity in mouse models, the team uncovered how sleep stimulates growth hormone release, while growth hormone simultaneously sends signals back to the brain that influence the transition to wakefulness 1.
The findings illuminate a finely balanced system between sleep and growth hormone regulation 1. According to the research, insufficient sleep reduces growth hormone release, while excessive growth hormone promotes the brain's shift toward wakefulness 1. "Sleep and growth hormone form a tightly balanced system: insufficient sleep reduces growth hormone release, and excessive growth hormone promotes the brain's transition to wakefulness," noted Daniel Silverman 1. Beyond muscle building and fat reduction, growth hormone may also provide cognitive benefits. "Growth hormone not only helps build muscle and bone and reduce fat tissue, but may also have cognitive benefits," Ding explained 1. These discoveries could open new therapeutic pathways for treating sleep disorders and neurodegenerative diseases 1. The research was supported by funding from the Howard Hughes Medical Institute and the Pivotal Life Sciences Chancellor's Chair 1.
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