加州大学洛杉矶分校研究人员发现，肠道菌群及其产生的化学物质与大脑衰老速度存在关联1。该研究对近1500名成年人进行了脑扫描和粪便样本分析，研究结果已发表在《eBioMedicine》期刊2026年第132卷1。
研究发现，脑衰老指数较高的人群在工作记忆和执行功能测试中表现更差，并报告更多抑郁症状1。这些脑衰老迹象与特定肠道菌群和代谢产物相关联，包括特定脂肪分子、胆固醇相关化合物以及较低水平的激素雌二醇1。
UCLA Health Goodman-Luskin微生物组中心联合主任Dr. Arpana Church指出，"脑衰老不是在我们变老时突然开始的，但生物信号可能在数十年前就能检测到"1。这表明脑衰老的生物信号可能在症状出现前数十年就已可检测到1。
A UCLA research team has discovered a potential link between gut bacteria, their chemical byproducts, and the rate at which the brain ages 1. The study, published in eBioMedicine in 2026 (volume 132, article 106468), examined nearly 1,500 adults through brain imaging and fecal sample analysis 1. Researchers found that individuals showing signs of accelerated brain aging performed worse on tests of working memory and executive function, reported more depressive symptoms, and exhibited distinct patterns in their gut microbiota and metabolic compounds 1.
The findings suggest that biological markers of brain aging may be detectable decades before symptoms become apparent 1. Individuals with higher brain aging indices demonstrated associations with specific lipid molecules, cholesterol-related compounds, and lower levels of the hormone estradiol 1. According to Dr. Arpana Church, co-director of the UCLA Health Goodman-Luskin Microbiome Center, "Brain aging does not suddenly begin as we grow older, but biological signals may be detectable many decades in advance" 1.
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