罗切斯特大学医学中心的研究发现，加强身体的自然昼夜节律可以促进小鼠在脑卒中后的恢复1。这一发现发表在《临床调查杂志》2026年第136卷第12期上，研究表明强化生物节律能改善大脑的废物清除系统（胶淋巴系统）的功能，同时降低持续性脑部炎症1。
研究团队测试了多种干预措施，包括时间光照、褪黑激素、KL001药物和时间限制进食1。值得注意的是，这些治疗方法即便在卒中后第三天才开始实施仍然有效，这远超越了急性卒中治疗通常的狭窄时间窗口1。结果显示，相关干预措施改善了小鼠的运动恢复，减少了病灶体积，并降低了脑部炎症细胞因子水平1。其中时间限制进食被认为是最有前景的方法之一，已在肥胖症、糖尿病和心血管疾病研究中得到应用1。
这项研究建立在近期神经科学的重要发现基础之上。Maiken Nedergaard在2012年发现了胶淋巴系统1，而Lauren Hablitz在2020年的标志性研究中进一步证实了胶淋巴功能受昼夜节律的影响，且这种影响独立于睡眠1。
Researchers at the University of Rochester Medical Center have discovered that strengthening the body's natural circadian rhythms can enhance brain recovery in mice after stroke by improving the brain's waste-clearance system and reducing persistent inflammation 1. The study, published in the Journal of Clinical Investigation in 2026, demonstrated that interventions including time-restricted feeding and KL001 medication improved motor recovery, reduced infarct volume, and lowered levels of inflammatory cytokines in the brain 1. Notably, these treatments remained effective even when initiated on the third day post-stroke, extending far beyond the narrow therapeutic window typically available for acute stroke treatments 1.
The research tested multiple interventions aimed at reinforcing circadian rhythms, including timed light exposure, melatonin, the KL001 drug, and time-restricted eating 1. The glymphatic system—the brain's waste-removal mechanism discovered by Maiken Nedergaard in 2012—operates according to circadian patterns, a relationship confirmed in a landmark 2020 study by Lauren Hablitz that demonstrated glymphatic function responds to circadian rhythms independently of sleep 1. Time-restricted feeding emerged as one of the most promising approaches and has already shown potential in research addressing obesity, diabetes, and cardiovascular disease 1.
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