9月21日世界阿尔茨海默病日期间，北京大学深圳医院神经内科举办公益义诊活动，强调应及时区分正常衰老与病理性记忆损伤1。专家指出，病理改变往往在临床症状出现前15—20年悄然发生1，但患者就诊率仍然偏低。
据统计，国内现存阿尔茨海默病及其他痴呆患者接近1700万，60岁以上群体中约3877万人存在轻度认知障碍1。令人遗憾的是，超六成阿尔茨海默病患者确诊时已发展到中重度阶段，轻度认知障碍人群就诊率仅为2.8%1。
医院通过临床案例展示了多学科诊疗的有效性。一位72岁患者确诊为抗LGI1抗体相关自身免疫性脑炎合并阿尔茨海默病，这是全球首次报道的混合病例1。通过采用"免疫冲击+靶向抗痴呆"平衡治疗方案，患者的精神状态和认知水平明显好转1。专家还列举了提示早期病变的信号，建议家属及时就诊评估1。
On September 21, World Alzheimer's Day, Peking University Shenzhen Hospital organized a public health consultation event featuring neurology specialists emphasizing the importance of differentiating normal cognitive decline from disease-related memory impairment 1. The hospital's theme for the occasion was "Early Recognition, More Memories Preserved" 1.
According to the event, approximately 17 million people in China currently live with Alzheimer's disease and other forms of dementia, while roughly 38.77 million individuals aged 60 and above experience mild cognitive impairment 1. However, more than 60 percent of Alzheimer's patients are diagnosed only after their condition has progressed to moderate or severe stages, and the medical consultation rate among those with mild cognitive impairment stands at merely 2.8 percent 1. Pathological changes typically begin 15 to 20 years before clinical symptoms become apparent 1.
The hospital presented a clinical case to illustrate diagnostic challenges and treatment approaches: a 72-year-old patient, Zhang Shu, was diagnosed with a rare mixed condition combining anti-LGI1 antibody-related autoimmune encephalitis and Alzheimer's disease, marking the first such globally reported case 1. Through a balanced treatment strategy combining "immune intervention and targeted anti-dementia therapy," the patient showed marked improvement in mental state and cognitive function 1. The event also provided 10 warning signs prompting family members to seek medical evaluation for their relatives 1.
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