英国医学研究委员会与伦敦帝国学院对近48万名英国成年人进行的研究发现，慢性压力和炎症可能在症状出现前数年就开始改变心脏结构1。研究表明，炎症水平最高的人群（前20%）患心脏病和中风的风险比炎症水平最低的人群（后20%）高43%1。这些心脏变化包括心壁增厚、心室变小和心脏充盈不佳1。
研究人员利用血液标记物GlycA来评估炎症水平，发现慢性炎症与社会经济地位、心理压力和生活方式密切相关1。其中，炎症相关蛋白如白细胞介素-1和TNF家族可能是心脏损伤的重要贡献者1。这一研究成果已发表于《欧洲预防心脏病学杂志》2026年刊，由英国医学研究委员会和英国心脏基金会资助1。
A large-scale study conducted by researchers from the Medical Research Council and Imperial College London has identified a significant link between chronic inflammation and cardiovascular disease risk.1 The investigation examined nearly 480,000 British adults and found that individuals with the highest inflammation levels faced a 43% greater risk of heart disease and stroke compared to those with the lowest inflammation levels.1 Notably, these cardiac changes may begin years before any symptoms become apparent.1
The research reveals that chronic inflammation and stress trigger structural alterations in the heart itself.1 Inflammation is closely associated with socioeconomic disadvantage and psychological stress, both of which influence lifestyle factors that compound cardiovascular risk.1 The specific cardiac changes identified include thickened heart walls, reduced ventricular size, and impaired cardiac filling.1 Inflammatory proteins such as interleukin-1 and members of the TNF family are believed to contribute to this heart damage.1
Scientists used the blood marker GlycA to assess inflammation levels across study participants, establishing a measurable link between systemic inflammation and structural heart disease.1 The findings, supported by funding from the Medical Research Council and the British Heart Foundation, were published in the European Journal of Preventive Cardiology in 2026.1 This discovery underscores chronic stress as a hidden threat to cardiovascular health, operating through inflammatory pathways that silently reshape cardiac anatomy long before heart attacks or strokes occur.1
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