来自科隆大学、哈佛医学院、杜塞尔多夫大学医院和柏林Charité医院的研究团队发现了帕金森病患者脑深部刺激治疗的关键神经机制。[1]研究人员发现，一个特定的脑网络通过20-35Hz的高β节律进行通信，是深部刺激产生治疗效果的基础。[1]这一发现首次同时捕捉了刺激效应的空间位置和时间特征，有望实现更精准的个性化治疗设置。[1]
该研究纳入50名患者的100个脑半球，采用了同时使用脑深部刺激植入电极和脑磁图（MEG）记录脑活动的方法。[1]研究结果表明，下丘脑核与前额叶皮层的连接强度与运动症状改善程度存在相关性。[1]相关成果已发表在《Brain》2026年第149卷第7期第2395页。[1]
Researchers from the University of Cologne, Harvard Medical School, and other institutions have identified a critical mechanism underlying deep brain stimulation therapy for Parkinson's disease patients.[1] The team found that a specific brain network communicates through high beta rhythms operating at 20–35 Hz, which forms the basis for the therapeutic effects of deep brain stimulation.[1] This discovery simultaneously captures both the spatial location and temporal characteristics of stimulation effects for the first time, potentially enabling more precise, personalized treatment settings.[1]
The research analyzed data from 100 brain hemispheres across 50 patients using simultaneous deep brain stimulation electrode implants and magnetoencephalography (MEG) recordings to track brain activity.[1] The study revealed that the strength of connectivity between the subthalamic nucleus and prefrontal cortex correlates directly with the degree of motor symptom improvement in patients.[1] The findings were published in Brain in 2026 (149(7): 2395) and were supported by funding from the Klaus Thiemann Professor Foundation.[1]