耶鲁医学院的研究团队发现了一种潜在的药物方法，可以模拟卡路里限制的抗衰老效果，而无需严格控制饮食。1这项研究成果已于2026年8月26日发表在《Nature Aging》杂志第6卷第5期。1
研究基于对42名参与美国国立卫生研究院资助的CALERIE两年研究的人员的观察。1这些参与者的卡路里摄入减少了11-14%，其中大多数人在两年内减重约18磅。1研究人员发现，适度卡路里限制会显著降低免疫蛋白C3的水平，而这一下降与体重减少无相关性。1C3与衰老相关的慢性炎症密切相关，其来源是白色脂肪组织中的年龄相关巨噬细胞。1
研究团队在小鼠实验中使用药物阻断C3的激活。1结果表明，药物阻断C3能有效减少与年龄相关的炎症。1这些发现表明，未来可能开发出针对C3的药物，为无法或不愿进行严格节食的人提供卡路里限制的健康益处。1
Researchers at Yale School of Medicine have discovered that moderate calorie restriction lowers levels of an immune protein linked to age-related inflammation, suggesting a potential pharmaceutical shortcut to the anti-aging benefits of dieting. The study, published in Nature Aging Volume 6, Issue 5 in August 2026, found that reducing calorie intake by 11-14 percent significantly decreased levels of complement protein C3, which plays a central role in chronic inflammation associated with aging.1
The research involved 42 participants in a National Institutes of Health-funded two-year study who reduced their caloric consumption by the specified amount, losing an average of approximately 18 pounds over the study period.1 Notably, the reduction in C3 levels occurred independently of weight loss, indicating that the protein's decline was a direct effect of calorie restriction rather than a consequence of reduced body mass.1 Age-related macrophages in white adipose tissue were identified as the source of C3 production.1
To test whether blocking C3 could replicate calorie restriction's benefits without requiring dietary changes, researchers pharmacologically inhibited C3 activation in mice and observed a corresponding reduction in age-related inflammation.1 These findings open the possibility of developing medications that could provide the anti-aging advantages associated with calorie restriction while eliminating the need for sustained dietary restriction.1
评论
还没有评论，欢迎留下第一条。