悉尼科技大学、哈佛大学和河南大学的研究人员联合开发了一种纳米粒子平台，可在脑癌手术中标记隐藏的癌细胞并在手术后摧毁残留的微观癌细胞 1。这项研究成果已发表在《Science Translational Medicine》期刊2026年第18卷第861期 1。
在小鼠模型中，该纳米粒子平台展现了显著效果 1。纳米粒子能够识别小至44微米的肿瘤细胞簇，超过现有临床成像工具的能力 1。接受治疗的小鼠在60天时的生存率达到100%，而仅接受手术的小鼠生存期为42天 1。研究发现治疗未导致可检测的神经学或运动损伤 1。
研究人员强调，这项研究仍处于早期阶段，尚未在人体中进行测试 1。鉴于胶质母细胞瘤五年生存率约为7% 1，该技术若能最终应用于临床，有望改善脑癌患者的预后。
Researchers from the University of Technology Sydney, Harvard University, and Henan University have developed a dual-function nanoparticle platform designed to identify concealed cancer cells during brain surgery and destroy microscopic residual tumors afterward 1. The innovation addresses a critical challenge in treating glioblastoma, a particularly aggressive form of brain cancer with a five-year survival rate of approximately 7% 1.
The nanoparticles can detect tumor cell clusters as small as 44 micrometers, surpassing the detection capabilities of existing clinical imaging tools 1. In mouse models, the treatment approach prevented tumor recurrence with a 100% survival rate at 60 days, compared to a 42-day median survival for mice receiving surgery alone 1. The therapy produced no detectable neurological or motor damage in the treated animals 1.
The findings, published in Science Translational Medicine, Volume 18, Issue 861, in August 2026 1, represent an early-stage development that has not yet been tested in human subjects 1. Researchers emphasized the preliminary nature of the work as the technology advances toward potential clinical applications 1.
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