24岁的深圳女孩袁媛在半年内经历了严重的健康危机[1]。她全身骨痛、体重从70斤暴瘦至50斤，一度被疑患骨癌[1]。北京大学深圳医院多学科团队通过PET-CT检查和血液检测，发现其血钙严重升高至3.92mmol/L（远超正常范围2.11-2.52mmol/L），甲状旁腺激素达正常值上限的20倍[1]，确诊为原发性甲状旁腺功能亢进[1]。
医疗团队成功切除了患者颈部的甲状旁腺腺瘤，该腺瘤重达6620毫克，是正常腺体的200倍[1]。术后9个月，患者体重回升30斤，全身骨痛症状消退[1]。医学团队指出，甲状旁腺功能亢进的临床误诊率极高，其症状分散在骨科、口腔科、肾内科等多个科室，容易导致患者求医过程的延长和误诊[1]。
A 24-year-old woman from Shenzhen experienced severe bone pain throughout her body and lost approximately 20 pounds over six months, with her weight dropping from 70 pounds to 50 pounds, initially raising suspicion of bone cancer [1]. A multidisciplinary team at Peking University Shenzhen Hospital identified the true cause through PET-CT imaging and blood tests, revealing dangerously elevated blood calcium levels and parathyroid hormone levels [1]. The diagnosis was primary hyperparathyroidism, a condition with an extremely high rate of clinical misdiagnosis whose symptoms are often scattered across multiple medical specialties including orthopedics, dentistry, and nephrology [1].
Laboratory results showed the patient's blood calcium at 3.92 mmol/L, far exceeding the normal range of 2.11-2.52 mmol/L, while her parathyroid hormone levels reached twenty times the upper limit of normal [1]. Surgeons successfully removed a parathyroid adenoma weighing 6,620 milligrams—approximately 200 times the weight of a normal parathyroid gland [1]. Within nine months following the operation, the patient regained 30 pounds and all symptoms of bone pain resolved [1].
