耶鲁大学医学院研究人员在《Nature Aging》上发表了一项新研究，发现适度限制卡路里摄入能够显著降低免疫蛋白补体成分3（C3）的水平，从而减轻与衰老相关的慢性炎症 1。这项发表于2026年8月26日的研究由耶鲁大学医学院病理学、免疫生物学与比较医学教授Vishwa Deep Dixit博士担任资深作者 1。
该研究基于NIH资助的CALERIE两年期试验，共有42名参与者将日常卡路里摄入减少了11%至14% 1。两年后，参与者的平均减重量约为18磅，但数据显示体重变化与C3蛋白水平的下降之间并不存在相关性 1。研究团队进一步揭示，内脏白色脂肪组织中的年龄相关巨噬细胞是C3蛋白的主要来源 1。
在动物实验中，研究人员发现使用药物抑制C3激活可减少小鼠的年龄相关炎症 1。研究团队目前正在探索使用FDA批准的抑制剂药物抑制C3产生，以延缓人类衰老 1。这一成果提示，未来或可通过药物模拟卡路里限制的抗衰老益处而无需严格节食 1。
Researchers at the Yale School of Medicine have discovered that moderate calorie restriction significantly reduces chronic inflammation associated with aging by lowering levels of the immune protein complement component 3 (C3) 1. The findings were published on August 26, 2026, in the journal Nature Aging and are based on the two-year CALERIE trial funded by the National Institutes of Health 1. This trial involved 42 participants who reduced their calorie intake by 11% to 14% 1. The senior author of the study is Dr. Vishwa Deep Dixit, a professor of pathology, immunobiology, and comparative medicine at the Yale School of Medicine 1.
The research team identified that age-related macrophages in visceral white adipose tissue are the main source of C3 1. While the participants lost an average of about 18 pounds after two years, the change in body weight did not correlate with the decrease in C3 protein levels 1. In addition, animal experiments showed that administering drugs to inhibit C3 activation reduced age-related inflammation in mice 1. Consequently, the researchers are now exploring the use of FDA-approved inhibitor drugs to suppress C3 production to delay human aging, which could potentially replicate the anti-aging benefits of calorie restriction without requiring strict dietary limitations 1.
评论
还没有评论，欢迎留下第一条。