由黄路生团队等多家机构联合研发的"中芯一号"家猪基因育种芯片荣获2025年国家科技进步一等奖[1]。该芯片实现了芯片设计、生产、扫描设备的100%国产化[1]，突破了长期被美国Illumina等西方巨头垄断的基因检测技术[1]。
该芯片单孔集成10万个位点，覆盖422个性状[1]，育种准确率比西方同类产品高出21%到22%[1]。量产后检测一头猪的成本从1200元降至100元[1]，降幅达90%，目前已占据国内92%市场份额[1]。为推动产业发展，"中芯一号"的12项核心专利对所有中国民族企业永久免费[1]。
黄路生团队为该成果付出了长期努力，历时30年走了47万公里收集本土猪基因[1]。研究中发现了多个重要基因功能：VRTN基因可使猪多长一对排骨，MYH4基因可提升肌内脂肪[1]。
China has successfully developed and commercialized "Zhongxin No. 1," a domestically designed and produced porcine genomic breeding chip that won the 2025 National Science and Technology Progress Award (First Prize)[1]. The chip was jointly developed by a team led by Huang Lushen and multiple institutions, including Jiangxi Agricultural University, Wens Foodstuff Group, Lasso Biotechnology, and Beijing Compusun[1].
The breakthrough represents a complete break from Western dominance in genetic detection technology, which has long been controlled by companies such as the United States' Illumina[1]. Zhongxin No. 1 achieves 100 percent domestication across chip design, manufacturing, and scanning equipment[1]. The single-pore chip integrates 100,000 genetic markers and covers 422 livestock traits, with breeding accuracy surpassing comparable Western products by 21 to 22 percent[1]. The Huang Lushen team devoted 30 years to the research, traveling 470,000 kilometers to collect indigenous pig genetic material[1].
The economic impact has been transformative. Testing costs plummeted from 1,200 yuan to 100 yuan—a 90 percent reduction—following mass production[1]. The chip has captured 92 percent of the domestic market share[1]. Additionally, 12 core patents underlying Zhongxin No. 1 have been made permanently royalty-free to all Chinese ethnic enterprises[1]. Scientific discoveries enabled by the chip include identifying the VRTN gene, which allows pigs to grow an extra pair of ribs, and the MYH4 gene, which enhances intramuscular fat content[1].
