华盛顿大学医学院圣路易斯分校的研究人员在小鼠颅骨骨髓中发现了具有淋巴结样特征的新型免疫"枢纽"结构，这些结构能够对脑肿瘤迅速做出免疫反应1。研究表明，破坏这些免疫枢纽会导致脑胶质母细胞瘤小鼠的肿瘤增长加快且存活时间缩短1。相反，通过刺激颅骨骨髓的免疫增强蛋白来强化免疫反应，能够帮助接受治疗的动物更有效地排斥肿瘤并延长存活时间1。
研究人员Jonathan Kipnis表示，"颅骨今后不应仅被视为大脑周围的保护外壳"1。相关成果已发表在《自然》杂志上，但目前的验证仅限于小鼠模型，该发现在人类身上的应用证据仍处于初步阶段，需要进一步研究1。
Researchers at Washington University School of Medicine in St. Louis have identified previously unknown immune structures within the skull bone marrow that function as lymph node-like "hubs," capable of mounting rapid responses to brain tumors. 1 The discovery, published in the journal Nature, reveals that these immune centers play a critical role in the body's defense against glioblastoma. 1
In experiments with mice, disrupting these immune hubs accelerated tumor growth and shortened survival times. 1 Conversely, stimulating immune-enhancing proteins in the skull bone marrow enabled treated animals to reject tumors more effectively and survive longer. 1 According to Jonathan Kipnis, a leading researcher on the project, "The skull should no longer be viewed simply as a protective shell around the brain." 1
While the findings are significant, the research has thus far been validated only in mice, and human applications remain in preliminary stages. 1
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