宾夕法尼亚大学研究人员开发了一种生物工程口香糖，在临床试验中展现了显著的抗病毒效果。[1] 该口香糖提取物能将唾液样本中的HPV病毒水平降低93%，在口腔漂洗样本中的降低幅度为80%。[1] 同时，单一剂量的治疗将与头颈癌相关的两种有害细菌——牙龈卟啉单胞菌（Pg）和核梭形单胞菌（Fn）的水平降至近乎零。[1]
该研究成果的另一个优势在于其安全性。[1] 这种治疗方法不会对口腔中的有益菌群造成损害，为更安全、更经济的疾病防治提供了新的可能性。[1] 研究团队负责人Henry Daniell表示，"全球口咽癌的增加与HPV感染相关，Pg和Fn感染会恶化未治疗的复发性或转移性口腔癌的生存率"。[1] 该项研究已发表在《Scientific Reports》期刊，获得美国国立卫生研究院（NIH）的资金支持。[1]
Researchers at the University of Pennsylvania have developed a bioengineered chewing gum capable of significantly reducing human papillomavirus (HPV) levels in the oral cavity. [1] In testing, the gum extract decreased HPV levels by 93% in saliva samples and 80% in oral rinse samples. [1] A single dose also reduced levels of Porphyromonas gingivalis (Pg) and Fusobacterium nucleatum (Fn)—two bacteria associated with head and neck cancer—to near-zero levels. [1]
The treatment preserves beneficial oral bacteria while targeting harmful pathogens, potentially offering a safer and more cost-effective therapeutic approach. [1] According to Henry Daniell, a researcher involved in the study, "The global increase in oropharyngeal cancer is linked to HPV infection, and Pg and Fn infections worsen survival rates in untreated recurrent or metastatic oral cancer." [1] The research, published in Scientific Reports and supported by an NIH grant (5-R01-HL 107904-13), was conducted by the University of Pennsylvania School of Dental Medicine research team. [1]