澳大利亚研究人员通过脑成像研究发现，裸盖菇素（魔法蘑菇中的致幻物质）能够显著改变大脑网络的组织方式1。该研究对62名无先前致幻剂使用经验的健康成年人进行了扫描，参与者接受19毫克裸盖菇素1，剂量与临床试验相似1。研究发现，大脑中处理内部世界和周围环境的网络变得不那么独立1。
在具体的神经影像指标上，视觉网络中睁眼和闭眼活动的差异缩小了85%，整个大脑网络的差异缩小了66%以上1。脑电图记录中，主要脑节律的睁眼和闭眼差异下降了48%1。参与者报告了一种称为"嵌入性"的体验——感到自己与周围世界连续统一，这与积极的心理变化相关联1。此外，半数参与者报告这是他们人生中最有意义的经历之一1。
该研究成果已发表在《自然》期刊1，并提供了迄今世界上最大的单中心致幻药物脑成像数据集1。研究团队已将名为PsiConnect的数据集公开可用1。
A brain imaging study of 62 healthy adults has demonstrated that psilocybin, the active psychedelic compound in magic mushrooms, fundamentally alters how neural networks communicate.1 Researchers administered 19 milligrams of psilocybin to participants with no prior experience using hallucinogens, using a dosage comparable to that employed in clinical trials.1 The findings, published in the journal Nature, represent the world's largest single-center neuroimaging dataset for hallucinogenic drug research to date.1
The MRI scans revealed striking changes in brain organization under the influence of psilocybin.1 The difference between eyes-open and eyes-closed activity in the visual network decreased by 85%, while differences across all major brain networks fell by more than 66%.1 EEG recordings showed a 48% decline in the distinction between eyes-open and eyes-closed patterns in primary brain rhythms.1 These neural reorganizations correlated with participants' reports of a phenomenon termed "connectedness"—a sense of dissolving into a continuous unity with the surrounding world.1 Half of the study participants described the experience as among the most meaningful of their lives.1
The research team has made the PsiConnect dataset publicly available for further scientific investigation.1
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