俄克拉荷马大学研究人员发现了三阴性乳腺癌促进自身生长的一个关键机制1。研究表明，肿瘤能够操纵免疫系统，通过招募巨噬细胞释放BDNF蛋白，从而吸引神经进入肿瘤组织1。该研究已发表在《细胞死亡与分化》期刊上1。
研究团队负责人Maureen Cox博士表示，"虽然巨噬细胞通常在体内发挥积极作用，但在乳腺癌这一场景中它们在促进一个负面功能"1。在小鼠实验中，使用BDNF阻断药物后，神经不再进入肿瘤，肿瘤生长得到显著减缓1。人类患者数据分析进一步证实了这一发现的临床意义：含有更高水平巨噬细胞和BDNF的肿瘤与更差的生存率相关1。这项研究得到了美国国立卫生研究院（NIH）和俄克拉荷马烟草结算信托基金的资助1。
Researchers at the University of Oklahoma have discovered a mechanism by which triple-negative breast cancer manipulates the immune system to promote tumor growth and drug resistance.1 The cancer cells recruit macrophages that release BDNF protein, which in turn attracts nerves to infiltrate the tumor.1 According to Dr. Maureen Cox, "Although macrophages typically play a positive role in the body, in the context of breast cancer they are promoting a negative function."1
The findings, published in Cell Death and Differentiation, were supported by laboratory experiments in which blocking BDNF with pharmaceutical agents significantly slowed tumor growth in mice, with nerves no longer infiltrating the tumors.1 Analysis of human patient data revealed that tumors with higher levels of macrophages and BDNF are associated with worse survival rates.1 The research was funded by the U.S. National Institutes of Health and the Oklahoma Tobacco Settlement Trust Fund.1
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