Rutgers大学研究团队使用PET脑成像技术对122人进行了研究，其中29人被诊断为精神分裂症，这是迄今规模最大的突触密度脑成像研究之一1。研究发现，精神分裂症患者脑内存在广泛的突触连接减少现象，且损失遵循有组织的模式，左半脑受到的损伤程度明显高于右半脑1。
这些突触损失最严重的脑区富含血清素、γ-氨基丁酸和谷氨酸等神经递质的高浓度受体1。通过计算机模拟脑的结构连接，研究人员识别出左前额叶可能是突触损失的起始点1。研究已发表于《Molecular Psychiatry》期刊1。Rutgers大学研究人员Avram Holmes表示："这种详细的突触脆弱性映射最终可能帮助确定在哪里以及如何干预以保护或恢复脑功能"1。
Researchers at Rutgers University have discovered that synaptic connection loss in schizophrenia patients follows an organized pattern rather than occurring randomly throughout the brain.1 Using PET brain imaging technology, the team analyzed 122 individuals, including 29 diagnosed with schizophrenia, in what represents one of the largest synaptic density imaging studies to date.1 The findings reveal that schizophrenia patients exhibit widespread reduction in synaptic connections, with significantly greater loss occurring in the left hemisphere compared to the right.1
The pattern of synaptic loss correlates with the concentration of neurotransmitter receptors and neural connectivity within specific brain regions.1 Brain areas showing the most severe loss contain high concentrations of receptors for serotonin, gamma-aminobutyric acid, and glutamate.1 Computer simulations based on the brain's structural connections identified the left prefrontal cortex as a likely starting point for synaptic loss.1 According to Avram Holmes, one of the researchers, "this detailed mapping of synaptic vulnerability may ultimately help determine where and how to intervene to protect or restore brain function."1 The study was published in Molecular Psychiatry.1
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