2026年5月至6月期间，在墨西哥特波茨兰（Tepoztlán）的Qualia研究所（QRI）静修活动中，一名匿名作者记录了使用强效致幻剂5-MeO-DMT后出现的视觉感知变化 1。作者在摄入约3.4毫克至6.8毫克的5-MeO-DMT后观察到，经典的“艾宾浩斯错觉”——即周围圆圈大小影响中心圆圈大小感知的现象——显著减弱甚至完全抵消，且这种变化似乎受注意力焦点控制 1。
这一现象与已知增强该错觉的其他致幻剂形成对比。2025年的一项研究表明，古典致幻剂裸盖菇素会使艾宾浩斯错觉增强，其中5毫克剂量下增强38%，10毫克剂量下增强59% 1。文章推测这种相反的视觉效果可能源于神经药理学机制的差异：古典致幻剂主要作为5-HT2a受体激动剂，而5-MeO-DMT主要作为5-HT1a受体激动剂 1。作者认为这一发现可能为将意识视为一种计算介质或电磁场现象的理论提供线索，并指出其主观上对电磁场意识理论的支持度概率更新增加了约5%，但强调目前仍处于初步观察阶段 1。
需要注意的是，该记录基于个人及少数参与者的主观报告，并非严格的双盲对照实验 1。此外，后续更高剂量的尝试未能复现该效果，表明相关结论仍需更多系统性研究来验证 1。
An anonymous author reported experiencing a significant reduction or complete cancellation of the classic Ebbinghaus illusion while under the influence of the potent hallucinogen 5-MeO-DMT 1. This subjective observation occurred during a retreat hosted by the Qualia Research Institute (QRI) in Tepoztlán, Mexico, between May and June 2026, after the participant consumed doses ranging from approximately 3.4 mg to 6.8 mg 1. The author noted that the perceived size distortion caused by surrounding circles seemed to be controlled by attentional focus 1.
This finding stands in direct contrast to established research on classical psychedelics, such as psilocybin, which typically enhances the Ebbinghaus illusion 1. A study conducted in 2025 demonstrated that psilocybin increased the magnitude of this visual illusion by 38% at a 5 mg dose and by 59% at a 10 mg dose 1. The author hypothesized that the divergent effects may stem from distinct neuropharmacological mechanisms, specifically noting that while classical psychedelics primarily act as 5-HT2a receptor agonists, 5-MeO-DMT functions mainly as a 5-HT1a agonist 1.
The report suggests that these observations might offer preliminary clues for theories viewing consciousness as a computational medium or electromagnetic field phenomenon 1. However, the author emphasized that this is an initial observation based on personal and limited participant reports rather than a rigorous double-blind controlled experiment 1. Notably, attempts to reproduce the effect using higher doses were unsuccessful, underscoring the need for further systematic research to validate these findings 1.
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