加州大学圣地亚哥分校医学院的研究团队发现，由运动触发的慢性下背痛会激活大脑中的默认模式网络（DMN），该网络通常与自我意识和身份认同密切相关 1。这一发现发表于2026年10月5日的《英国麻醉学杂志》，指出慢性疼痛在神经机制上与急性疼痛存在显著差异：急性热刺激通常会抑制DMN的活动，而慢性疼痛则将其激活 1。
通过对114名慢性下背痛患者进行研究，团队揭示了为何传统止痛药对这类疼痛往往效果有限，因为疼痛体验可能与患者的个人身份深度交织 1。该研究通讯作者Fadel Zeidan博士及相关团队探讨了正念冥想和裸盖菇素等新型疗法，认为这些方法可能通过改变患者与疼痛的关系来提供新的治疗途径 1。这项研究得到了美国国立卫生研究院国家补充与整合健康中心Grant #R01AT009693的资金支持 1。
Researchers at the University of California San Diego School of Medicine have discovered that movement-triggered pain in chronic lower back conditions activates the brain’s default mode network (DMN), a region associated with self-awareness and personal identity 1. This finding, published on October 5, 2026, in the British Journal of Anaesthesia, reveals a distinct neural mechanism that differs significantly from the response to acute pain 1. The study suggests that chronic pain may be deeply intertwined with an individual's sense of self, offering new explanations for why traditional analgesics often fail to provide sufficient relief 1.
The investigation involved 114 patients suffering from chronic lower back pain and demonstrated that while acute thermal stimuli typically suppress the DMN, the persistent pain experienced during movement triggers its activation 1. Led by corresponding author Dr. Fadel Zeidan, the team posits that this neurological link helps explain the subjective nature of chronic pain and its resistance to conventional treatments 1. Consequently, the researchers are exploring potential therapies such as mindfulness meditation and psilocybin, which may help alter a patient’s relationship with their pain rather than solely targeting nociceptive signals 1. This research was funded by Grant #R01AT009693 from the National Center for Complementary and Integrative Health at the National Institutes of Health 1.
评论
还没有评论，欢迎留下第一条。