浙江大学研究团队在《自然·通讯》发表的一项大规模研究表明，慢性病患者数量越多，日后出现孤独感的风险越高1。这项研究覆盖了19个国家超过11万名中老年人，揭示了孤独感与慢性病共病之间相互加重的关系1。
孤独问题已成为全球公共卫生关注的焦点。世卫组织在2025年6月的报告中指出，全球约六分之一的人受孤独困扰，孤独与每年超过87万例死亡相关1。由浙江大学周亚冠博士担任第一作者、徐小林研究员为通讯作者的这项研究，提示慢性病管理应重视患者的社会活动和心理状况，而不仅关注生理指标1。
A large-scale international study involving over 110,000 middle-aged and elderly people across 19 countries has found that individuals with more chronic diseases face a higher risk of experiencing loneliness in the future.1 The research, published in Nature Communications by a team from Zhejiang University, reveals a mutually reinforcing relationship between loneliness and comorbid chronic conditions.1
The findings underscore the need for a more comprehensive approach to chronic disease management that extends beyond monitoring physical health indicators. According to the research, managing chronic diseases should place greater emphasis on patients' social engagement and psychological well-being.1 The study was led by Dr. Zhou Yaguan from Zhejiang University, with Professor Xu Xiaolin from the university's School of Public Health serving as the corresponding author.1
The research carries particular significance given the scale of loneliness as a global health concern. The World Health Organization reported in June 2025 that approximately one in six people worldwide struggle with loneliness, which is associated with more than 870,000 deaths annually.1
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