布鲁塞尔自由大学与剑桥大学的研究人员通过对小鼠皮肤干细胞进行为期五个月的追踪观察，揭示了性别之间存在的显著差异1。研究发现，雌性小鼠的皮肤干细胞表现出高度协调的工作方式，而雄性干细胞则更多地独立运作1。这种差异由性激素调控，其中雌激素促进干细胞增殖并协调细胞行为，而睾酮则加快细胞分化成熟1。
研究通过一系列对照实验验证了激素的作用机制1。当移除睾酮后，雄性小鼠皮肤细胞行为转变为更接近雌性模式；给予二氢睾酮后则恢复为雄性特征1。卵巢切除减少了干细胞增殖并消除了姐妹细胞的同步性，而给予雌二醇后这些效应得到部分恢复1。
这些性别间的生物学差异在伤口愈合中产生了实际影响1。雌性小鼠的伤口闭合速度明显更快，尤其是在受伤后最初几天1。该研究由塞德里克·布朗潘教授领导，已发表在《自然》期刊1。
Researchers from Vrije Universiteit Brussel and the University of Cambridge have identified fundamental differences in how male and female skin stem cells behave, with implications for wound healing and skin regeneration.1 By tracking skin stem cells in mice over five months, the team found that female stem cells work in highly coordinated fashion, while male cells operate more independently.1 This divergence is controlled by sex hormones: estrogen promotes stem cell proliferation and coordinates cellular behavior, while testosterone accelerates cell differentiation and maturation.1
The research demonstrates these hormonal effects through targeted intervention.1 When testosterone was removed from male mice, their skin cells began behaving similarly to female cells; administering dihydrotestosterone restored the male pattern.1 Conversely, ovariectomy reduced stem cell proliferation in female mice and eliminated sister cell synchronization, though these effects were partially reversed by estrogen treatment.1 Functionally, female mice showed significantly faster wound closure than males, particularly in the critical first days following injury.1 The study, led by Professor Cedric Blanpain, was published in the journal Nature.1
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