西奈山医学院研究团队在《美国精神病学杂志》发表研究，确定了三条脑白质通路与深脑刺激治疗抵抗性抑郁症的长期缓解相关1。这三条关键通路分别为额叶束、强直小束和内侧钩束/腹侧杏仁核逃离通路1。
研究人员通过分析BROADEN临床试验及多个独立研究中心的患者数据发现，两年后未见治疗改善的患者存在共同特征——左侧额叶束刺激不足1。这一发现表明，电极植入部位仅相差几毫米的差异，也可能导致治疗效果出现显著不同1。在包括Abbott TRANSCEND在内的临床试验中，研究成果已被应用于指导个体化脑连接图手术1。
Researchers at Mount Sinai School of Medicine have discovered three white matter pathways in the brain that are linked to long-term relief from treatment-resistant depression when targeted with deep brain stimulation. 1 The findings, published on October 1, 2026, in the American Journal of Psychiatry, identified the cingulum bundle, forceps minor, and medial uncinate fasciculus/ventral amygdalofugal pathways as critical structures for treatment success. 1
The study revealed an important distinction among patients: those who showed no improvement after two years shared a common characteristic—insufficient stimulation of the left-side cingulum bundle. 1 This variation suggests that electrode placement differences of just millimeters can significantly influence treatment outcomes, even when implants are positioned in similar anatomical locations. 1 The research drew on patient data from the BROADEN clinical trial and multiple independent research centers. 1 These findings have practical implications for surgical planning, as evidenced by the Abbott TRANSCEND clinical trial, which now uses individualized brain connectivity mapping to guide electrode placement. 1
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