南加州大学科学家开发出一种利用粒单祖细胞（GMPs）创建可再生癌症免疫细胞的新方法。1研究团队通过开发精确定义的化学混合物，使这种未成熟免疫细胞能在实验室条件下存活和增殖数周甚至更长时间，同时保持分化成功能性免疫细胞的能力。1这一发现打破了之前认为仅有造血干细胞具有长期自我更新能力的传统理论。1
科学家对改造细胞进行了CAR基因工程处理，使其能识别和攻击肿瘤。1在小鼠模型实验中，携带CAR受体的粒单祖细胞既延缓了血液肿瘤的进展，也延缓了实体瘤的进展。1携带CAR受体和额外免疫激活信号的改造细胞表现出更强的效果。1此外，改造后的细胞能在骨髓中定植并持续产生新的免疫细胞。1
这项研究成果已发表在《Cell》期刊2026年第189卷第17期。1领导研究的Qi-Long Ying教授表示，"免疫疗法的未来可能不仅取决于设计更好的CAR受体，还取决于选择正确的细胞发育阶段"。1该方法潜在应用前景包括开创非个性化的现成疗法，无需为每位患者单独制备细胞，而是可提前批量生产供多位患者使用。1
Researchers at the University of Southern California have developed a technique to generate a renewable source of immune cells capable of targeting tumors, potentially revolutionizing cancer immunotherapy. 1 The method leverages granulocyte-monocyte progenitors (GMPs), immature immune cell precursors, which scientists have engineered to recognize and attack cancer cells through CAR genetic modification. 1
The breakthrough challenges conventional understanding by demonstrating that GMPs can maintain long-term self-renewal capacity under specific laboratory conditions, a capability previously believed to be exclusive to hematopoietic stem cells. 1 The research team developed a precisely defined chemical formulation that allows GMPs to survive and proliferate in the laboratory for weeks or longer while retaining their ability to differentiate into functional immune cells. 1 In mouse models, GMPs equipped with CAR receptors both delayed the progression of blood cancers and solid tumors, with enhanced effectiveness achieved when GMPs carried both CAR receptors and additional immune activation signals. 1
This advancement opens the possibility of off-the-shelf therapies that do not require individualized cell preparation for each patient; instead, cells could be produced in bulk batches for use across multiple patients. 1 Qi-Long Ying, the professor leading the research, stated: "The future of immunotherapy may depend not only on designing better CAR receptors, but on selecting the right developmental stage of cells." 1 The findings were published in Cell in 2026, volume 189, issue 17 (DOI: 10.1016/j.cell.2026.05.043). 1
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