冷泉港实验室研究人员发现，通过在免疫细胞中激活PPARD蛋白，可以增强这些细胞燃烧脂肪的能力，进而更有效地攻击肿瘤细胞。1研究团队负责人Semir Beyaz表示："这都关乎细胞的适应性。细胞摄入的物质决定了它们的特性。当免疫细胞燃烧更多脂肪时，它们就更适合用于抗击癌症。"1
在实验室研究中，被激活PPARD蛋白的CAR-T细胞在多个肿瘤模型中减缓或阻止了肿瘤生长，这一方法在结直肠癌、乳腺癌、卵巢癌和黑色素瘤上均显示出应许前景。1相关研究成果已发表于《自然免疫学》杂志。1
Researchers at Cold Spring Harbor Laboratory have discovered that activating the PPARD protein in immune cells enables them to burn fat more efficiently and attack tumors more effectively, potentially slowing or halting cancer growth.1 In laboratory experiments, this approach showed promising results against colorectal cancer, breast cancer, ovarian cancer, and melanoma.1 The findings have been published in the journal Nature Immunology.1
The research centers on enhancing the fitness of immune cells through metabolic manipulation. According to Semir Beyaz, a lead researcher on the team, "It's all about cell fitness. What cells eat affects who they are. When immune cells burn more fat, they become more fit for fighting cancer."1 PPARD-activated CAR-T cells demonstrated the ability to reduce or prevent tumor growth across multiple experimental models.1 Colorectal cancer has emerged as a leading cause of cancer-related deaths among people under 50 years old.1
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