世界卫生组织与国际组织联合推出全球框架，致力于消除人类狂犬病1。根据框架内容，防控的三大关键行动分别是降低人类疫苗和抗体成本、确保被咬伤者获得及时治疗，以及实施大规模犬类疫苗接种计划1。
狂犬病仍是全球重大公共卫生威胁。全球每10分钟有1人死于狂犬病1，亚洲和非洲承受最大疾病负担1，其中40%的死亡者为15岁以下儿童1。目前约80%的狂犬病暴露人群生活在非洲和亚洲的贫困农村地区1。
成本障碍是防控面临的主要挑战。人类疫苗价格为40至50美元，相当于一些受影响国家平均40天的工资1，而犬类疫苗成本不足1美元1。研究表明，对70%的犬类进行定期疫苗接种可将人类病例降至零1。截至2015年，世卫组织与世界动物卫生组织疫苗库已在多国交付超过1500万剂犬类狂犬病疫苗1。全球会议将于2015年12月10至11日召开，正式采纳该行动计划1。
The World Health Organization, together with international partner organizations, has introduced a comprehensive global framework aimed at eradicating human rabies worldwide.1 The initiative addresses a disease that claims tens of thousands of lives annually, with one person dying from rabies every ten minutes globally.1 Asia and Africa bear the heaviest burden of the disease, with approximately 80% of rabies exposures occurring among people living in impoverished rural areas.1
The framework centers on three critical interventions: reducing the cost of human vaccines and immunoglobulins, ensuring timely post-exposure treatment for bite victims, and implementing mass canine vaccination programs.1 Currently, human rabies vaccines cost between US$40 and US$50, equivalent to forty days' wages in some affected countries, while canine vaccines cost less than US$1.1 Vaccinating 70% of the dog population could reduce human rabies cases to zero.1 Approximately 40% of rabies deaths occur in children under fifteen years old.1
The WHO and World Organization for Animal Health vaccine stockpile has already delivered over 15 million doses of canine rabies vaccine to multiple countries as of 2015.1 A global conference scheduled for December 10–11, 2015, will formally adopt the action plan to implement this framework.1
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