约翰英尼斯中心的研究人员发现了一种新的植物免疫防御策略，通过工程改造串联激酶蛋白（TKPs）中的HMA结构域，使其能够同时识别多种真菌效应子1。这一发现为应对稻瘟病菌对全球主要谷物的威胁提供了潜在的解决方案。稻瘟病菌每年造成的水稻损失足以养活约6000万人1。
该研究由约翰英尼斯中心与日本神户大学合作完成，成功证明了改造后的TKP免疫受体具有双特异性，能够识别两种不同的真菌效应子1。研究团队负责人Mark Banfield教授表示："我们发现了可能导致干预谷物最严重真菌病害的潜在方案"1。研究已发表于2026年《科学进展》杂志第12卷第39期1。
下一步，研究人员需要在温室条件下的完整植物中验证这些改造受体的有效性1，以期为水稻、小麦和大麦等主要粮食作物提供长期的抗病保护，保障全球粮食安全。
Researchers at the John Innes Centre have developed a novel plant immune defense mechanism designed to combat a devastating fungal pathogen that endangers crops worldwide 1. By engineering the HMA domain within tandem kinase proteins (TKPs), scientists successfully created immune receptors capable of recognizing multiple fungal effectors simultaneously 1. This breakthrough, published in Science Advances in October 2026, offers a potential new strategy to protect rice, wheat, and barley from blast fungus, a pathogen responsible for annual rice losses sufficient to feed approximately 60 million people 1.
The study represents international collaboration between the John Innes Centre in the United Kingdom and Kobe University in Japan 1. The engineered receptors demonstrated dual-specificity, enabling them to identify two different fungal effectors 1. Mark Banfield, a professor involved in the work, stated: "We have discovered a potential solution that could intervene in the most severe fungal disease of cereals" 1. However, researchers emphasize that the next phase of validation will involve testing the modified receptors in complete plants under controlled greenhouse conditions before broader application 1.
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