明尼苏达大学研究团队首次成功将冷冻保存超过一年的猪肾脏解冻并恢复其功能1。这一突破采用玻璃化冷冻技术与氧化铁纳米粒子电磁加热复温相结合，将肾脏保存在零下150摄氏度的极低温环境中1。经过约2小时的冷冻保护剂准备和7至8分钟的纳米粒子灌注，解冻后的肾脏在约1分钟内开始产生尿液1。
解冻后的肾脏在灌流装置和移植到活体猪体内的实验中均恢复了血流功能，产生的尿液约为正常水平的三分之二1。虽然器官功能略低于正常水平且显示轻微损伤，但这一成果为实现人体器官银行的长期保存奠定了基础1。明尼苏达大学移植外科医生埃里克·芬格表示1："完成最后一次移植后，我走出房间说，'这是一件大事。'"此前，器官保存的极限仅为24至36小时1。
Researchers at the University of Minnesota have achieved a major breakthrough in organ preservation by successfully thawing and restoring function to pig kidneys that had been frozen at -150°C for more than a year 1. The kidneys were rewarmed using a combination of vitrification, a glass-like freezing technique, and electromagnetic heating powered by iron oxide nanoparticles 1. After thawing, the organs demonstrated restored blood flow and began producing urine within approximately one minute 1.
The revived kidneys showed functional capacity in both laboratory perfusion systems and when transplanted into living pigs, though their output measured approximately two-thirds of normal urine production levels 1. The researchers completed the process of preparing the cryoprotectant in roughly two hours, followed by seven to eight minutes of nanoparticle infusion 1. While the kidneys displayed minor damage and slightly reduced function compared to healthy organs, the successful long-term preservation represents a critical step toward establishing organ banks for transplantation 1.
Erik Finger, a transplant surgeon at the University of Minnesota, remarked after the final transplant: "This is a big deal" 1. Kevin Myer, president and CEO of LifeGift, an organ procurement organization in Texas, emphasized the significance: "It's a very big deal to go a year" 1.
Currently, organ preservation is limited to 24 to 36 hours, a constraint that has restricted transplant logistics across the United States, where tens of thousands of organ transplants are performed annually and have saved two million years of life over the past 25 years 1.
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