一项最新系统评审研究对长期以来关于皮质醇引发生育问题的广泛观点提出了挑战1。该研究发表在《实验生物学杂志》，通过对约3000项既往研究进行筛选和分析，从中鉴别出68项直接报告了健康女性卵巢周期不同阶段天然皮质醇水平的研究1。结果表明，在这些研究中，约73%报告了健康卵巢周期中皮质醇存在明显变化1。
研究人员的关键发现是，皮质醇水平通常在排卵时升高，这表明皮质醇增加可能实际上在驱动排卵等关键生殖事件中发挥重要作用，从而促进而非阻碍健康生殖1。研究团队认为，之前使用合成皮质醇注射进行的研究未能考虑天然皮质醇在生理周期中的实际变化模式，这导致了对这一激素作用的误解1。
A comprehensive systematic review published in the Journal of Experimental Biology questions the commonly held assumption that elevated cortisol levels impair reproductive function 1. Researchers examined approximately 3,000 studies and identified 68 that reported natural cortisol levels across different phases of the ovarian cycle 1. Among these 68 studies, 73 percent documented significant cortisol fluctuations during healthy ovarian cycles, with cortisol levels frequently rising at the time of ovulation 1.
The findings suggest that cortisol may actually support rather than undermine fertility 1. The research team discovered that increased cortisol concentrations appear to play a crucial role in driving key reproductive events such as ovulation 1. According to the researchers, earlier investigations that relied on synthetic cortisol injections may have produced misleading conclusions because they failed to account for the natural patterns of cortisol in the body, leading to widespread misunderstandings about how this hormone functions in reproduction 1.
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