塞达斯-西奈医学中心的研究人员揭示了有害衰老细胞如何在体内隐匿的机制。1研究发现，PD-L2蛋白可能帮助这些衰老细胞逃避免疫系统检测，从而在体内积累。1研究首席作者Selim Chaib博士表示："我们的发现表明PD-L2可能帮助衰老细胞在免疫系统本应清除它们时留在体内。"1
在实验小鼠中，研究人员阻断了这种蛋白，取得了显著效果。1阻断PD-L2后，小鼠体内衰老细胞的积累减少，炎症物质释放水平下降，同时小鼠的血糖处理能力改善，握力也得到增强。1此外，科研团队观察到衰老的人类细胞产生更多PD-L2，且该蛋白质水平随年龄增长而上升。1研究资深作者James Kirkland博士指出："如果我们能找到阻断这种蛋白的方法，可能能帮助免疫系统清除这些细胞，并可能改善与衰老相关的健康问题。"1这项研究已发表于《细胞代谢》期刊。1
Researchers at Cedars-Sinai Medical Center have identified a mechanism by which senescent cells—often called "zombie cells"—escape detection by the immune system and accumulate in the body.1 The team found that the protein PD-L2 appears to shield these aging cells from immune clearance, opening a new therapeutic avenue for age-related diseases.1
In experiments with mice, blocking PD-L2 reduced the buildup of senescent cells and lowered inflammation levels while improving blood sugar regulation and muscle strength.1 The findings, published in Cell Metabolism, reveal that aged human cells produce higher levels of PD-L2, with protein levels rising as people grow older.1 Dr. Selim Chaib, the study's lead author, explained that "our findings suggest PD-L2 may help senescent cells remain in the body when the immune system should be clearing them."1 According to senior researcher Dr. James Kirkland, "if we can find ways to block this protein, we may be able to help the immune system eliminate these cells, and potentially improve health issues associated with aging."1
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