深圳中山妇产医院生殖医学中心完成了华南地区首例CAPA-IVM临床妊娠1。这项创新技术无需使用促排卵药物，为患者提供了新的助孕选择1。
CAPA-IVM技术的核心在于无需使用促排卵药物1。医疗团队在患者月经第6天实施小卵泡穿刺，直接采集体内自然状态下的未成熟卵母细胞1。患者通过此次穿刺获取了三十余枚未成熟卵子1。这些卵子经双相体外成熟培养完成受精，最终成功冻存6枚囊胚1。患者于2026年8月完成冻融单囊胚移植后确认临床妊娠1。
根据临床数据，小卵泡穿刺获卵率稳定超过80%，参与该技术的患者平均可获得5枚以上可利用胚胎，临床妊娠率达到60%以上1。深圳中山妇产医院于2024年启动技术筹备，2026年3月正式立项临床研究项目，同年6月开展了首例临床操作1。
Shenzhen Zhongshan Women and Children's Hospital's Reproductive Medicine Center has successfully completed South China's first clinical pregnancy using CAPA-IVM technology, a novel assisted reproductive technique that eliminates the need for ovulation-stimulating medications 1. The procedure works by directly retrieving immature egg cells from the body in their natural state, followed by dual-phase in vitro maturation, fertilization, and embryo transfer 1.
The patient underwent her first procedure in June 2026 without receiving any ovulation-inducing drugs 1. On the sixth day of her menstrual cycle, small follicle puncture was performed to retrieve over thirty immature oocytes 1. Following successful maturation and freezing of six blastocysts, a single frozen-thawed embryo was transferred in August 2026, confirming clinical pregnancy 1. The hospital had begun preparations for this technology in 2024, formally launched the clinical research project in March 2026, and conducted the first clinical procedure in June 2026 1.
The CAPA-IVM technique demonstrates promising clinical outcomes, with a stable retrieval rate exceeding 80% through small follicle puncture 1. Patients typically obtain five or more viable embryos on average, with clinical pregnancy rates reaching over 60% 1.
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