意大利米兰理工大学与神经基金会研究团队联合开发了一种创新技术，利用金属有机框架（MOF）材料对线粒体进行涂层处理1。这项由 Dr. Valeria Tiranti 和 Professor Pierangelo Metrangolo 主导的研究成果已发表在《美国化学会杂志》上1。
该涂层工艺的关键优势在于能够修饰线粒体表面，同时保持其产生能量的基本功能完整1。研究人员证实，经过涂层处理的线粒体继续正常生成细胞能量1。这一发现为线粒体相关疾病的治疗打开了新的可能性，特别是在线粒体移植领域——通过将健康的涂层线粒体导入功能障碍的细胞中来实现治疗1。
不过，该技术仍需进一步验证。涂层线粒体在移植过程中的实际效果尚未得到充分证实，研究者需要开展额外研究以比较涂层线粒体与未涂层线粒体的移植表现1。
Researchers from Italy's Politecnico di Milano and IRCCS Fondazione Istituto Neurologico Carlo Besta have developed a novel technique to coat mitochondria with metal-organic frameworks (MOF) while preserving their energy-generating capacity 1. Led by Dr. Valeria Tiranti and Professor Pierangelo Metrangolo, the collaboration between the university's BraiNs laboratory (established in 2023) and the neural foundation demonstrates that coated mitochondria continue to produce energy, indicating the process can modify their surface without damaging core function 1. The findings, published in the Journal of the American Chemical Society, utilize MOF materials—a class of compounds recognized with the 2025 Nobel Prize in Chemistry, awarded to Susumu Kitagawa, Richard Robson, and Omar Yaghi 1.
The breakthrough opens potential pathways for treating mitochondrial diseases through therapeutic mitochondrial transplantation, where healthy mitochondria could be introduced into cells harboring dysfunctional organelles 1. However, researchers acknowledge significant limitations remain. The actual effectiveness of transplanting coated mitochondria has not yet been verified, requiring further investigation to determine whether the coating enhances transplant outcomes compared to uncoated mitochondria 1. The project received funding from the Italian Ministry of Health's "CALabria HUB per Ricerca Innovativa ed Avanzata" initiative under the Operational Health Plan 1.
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