华盛顿大学研究团队利用DNA Typewriter技术成功追踪了小鼠胚胎从受精卵第一次分裂到器官形成的全过程1。这项研究覆盖了胚胎发育前13.5天的时间段1，为理解正常发育过程及其失常机制提供了新的科学依据。
研究人员从100个受精卵开始进行实验，最终获得了10个可供检查的胚胎，其中胚胎3号提供了最为详尽的发育数据1。研究发现，两个初始细胞产生了几乎相等比例的多种专化细胞类型1。不同的细胞类型按各自独立的时间表承诺其分化命运，其中血细胞和视网膜相对较早完成分化承诺，而皮肤外层的分化承诺时间则明显较晚1。该研究成果已于2026年10月8日发表在《科学》杂志上1，得到了美国国立卫生研究院等多家机构的资助支持1。
Researchers at the University of Washington have successfully tracked the complete developmental journey of a mouse embryo from its first cell division through organ formation using an innovative DNA recording technology.1 The study documented the embryonic development across the first 13.5 days, a period representing the early stages of the mouse gestation cycle, which typically lasts 19 to 21 days.1 The findings, published in Science on October 8, 2026, demonstrate how different cell types commit to their specialized fates according to distinct independent timelines.1
The research team, led by scientists including Jay Shendure and Chengxiang Qiu, employed the DNA Typewriter technique to capture cellular lineage information throughout development.1 Starting with 100 fertilized eggs, researchers were able to examine 10 embryos in detail, with embryo number 3 providing the most comprehensive data.1 The analysis revealed that the two initial cells generated nearly equivalent proportions of diverse specialized cell types, while different tissues showed varied commitment timing—blood cells and retinal cells committed to their fates relatively early, whereas the outer skin layer committed much later.1 This work advances scientific understanding of normal developmental processes and provides insights into mechanisms when development goes awry.1
评论
还没有评论，欢迎留下第一条。