由崖州湾国家实验室、华大生命科学研究院等12个科研团队联合完成的水稻全生命周期时空细胞图谱已在国际学术期刊《细胞》发表。1这一研究成果覆盖了从种子萌发到开花结实的全过程，涵盖10类器官或组织、61个发育阶段，通过整合基因组、细胞发育阶段与空间转录组等多维信息，注释出119种细胞类型和133个细胞亚型。1研究团队获取了超85万个高质量细胞核的数据和超34万个空间数据单元，为水稻发育过程的细胞学研究提供了完整的数据支撑。1
研究采用粳稻品种中花11作为材料，已于10月6日晚在《细胞》期刊在线发表。1科研人员发现胚乳存在精细的空间分工——背侧周缘区域富集淀粉合成基因，腹侧周缘区域则偏向储藏蛋白合成基因。1同时识别出关键调控因子OsARF1能在不同空间和发育时期参与不同的分子调控网络。1为便于学术共享，团队建立了交互式在线图谱平台，并开发了水稻单细胞基础模型RICE scGPT，为全球科研工作者提供公共资源。1
A collaborative research team has completed a comprehensive spatiotemporal cellular atlas of rice spanning its entire developmental journey from seed germination to flowering and grain formation 1. The atlas integrates genomic data, cellular developmental stages, and spatial transcriptomic information to characterize 119 cell types and 133 cellular subtypes across 10 organ or tissue categories at 61 developmental stages 1. The research collected high-quality data from over 850,000 individual cell nuclei and more than 340,000 spatial data units 1.
The project, led by the Yazhou Bay National Laboratory and the BGI Genomics Institute of Life Sciences among 12 participating research institutions, utilized the japonica rice cultivar Zhonghua 11 as its study material 1. The findings were published online in the international journal Cell on October 6 1. The team identified spatial functional specialization within the rice endosperm, with the dorsal peripheral region enriched in starch synthesis genes while the ventral peripheral region favoring genes for storage protein synthesis 1. Additionally, researchers discovered that the key regulatory factor OsARF1 participates in distinct molecular regulatory networks across different spatial locations and developmental stages 1.
To maximize accessibility for the global research community, the team established an interactive online atlas platform and developed RICE scGPT, a single-cell artificial intelligence model for rice 1. These resources serve as public research tools supporting future studies in rice biology and crop improvement 1.
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