明尼苏达大学研究人员发现了一种控制牙周病的新途径，能够针对性地抑制有害菌种而保留口腔中的有益细菌。1研究团队通过干扰细菌进行通讯的化学信号——N-酰基高丝氨酸内酯（AHLs）分子，可以改变牙菌斑中的微生物群落组成，将其推向更健康的平衡状态。1
人类口腔中存在约700种细菌，其中某些细菌依靠AHL分子进行群体通讯。1研究人员发现，使用乳糖酶（lactonases）可以破坏这些信号分子。1在龈线上方的有氧环境中干扰AHL信号有利于健康相关菌种生长，而在龈线下方的无氧环境中添加AHL则促进与疾病相关的后期定植菌生长。1
该研究成果已发表于2025年《npj Biofilms and Microbiomes》期刊，研究资金来自美国国立卫生研究院（NIH）。1
Scientists at the University of Minnesota have identified a novel approach to treating gum disease by selectively disrupting harmful bacteria without eliminating the beneficial microorganisms essential for oral health.1 The breakthrough centers on interfering with N-acyl homoserine lactones (AHLs), chemical signals that certain oral bacteria use to communicate with one another.1
The human mouth hosts approximately 700 bacterial species, many of which play crucial roles in maintaining oral health.1 Researchers found that by deploying lactonases—enzymes that break down AHL signaling molecules—they can shift the microbial community composition in dental plaque toward a healthier balance.1 The strategy works differently depending on location: disrupting AHL signals in oxygen-rich environments above the gum line promotes the growth of health-associated bacteria, while adding AHL molecules in oxygen-poor environments below the gum line encourages the colonization of disease-related bacteria that establish later in biofilm development.1
The findings, published in 2025 in the journal npj Biofilms and Microbiomes, suggest a promising pathway for treating periodontal disease by controlling pathogenic bacteria while preserving the oral microbiome's beneficial components.1 The research was supported by funding from the National Institutes of Health.1
评论
还没有评论，欢迎留下第一条。