伦敦城市大学圣乔治分校研究团队近日发表研究成果，提出一种基于进化论原理的癌症治疗新策略1。该策略建议在肿瘤仍处于缩小阶段时主动切换化疗方案，而不是等待肿瘤复发后才改变治疗方式，以此阻止癌细胞进化适应1。数学模型研究表明，精心安排的多疗法快速切换可以有效防止肿瘤产生耐药性1。
研究由该校数学系高级讲师Robert Noble博士领导，成果已发表在《遗传学》期刊2026年第232卷第2期1。模型预测显示，两种治疗方案的切换可能仅在相对较小的肿瘤中取得成功，而三种或更多疗法的序列切换则可能消除更大规模的肿瘤1。该研究团队还包括来自印度科学教育研究所的学生Srishti Patil、约翰霍普金斯大学本科生Armaan Ahmed，以及巴黎第一大学的Yannick Viossat博士1。
目前已有三项临床试验正在进行中，分别针对软组织癌、前列腺癌和乳腺癌展开1。
Researchers at St. George's, University of London have developed a novel approach to cancer treatment that applies evolutionary principles to prevent tumors from developing drug resistance.1 The strategy centers on switching between chemotherapy regimens while tumors are still shrinking, rather than waiting for cancer to recur before changing treatment protocols.1
A mathematical model developed by the research team, led by Dr. Robert Noble, a senior lecturer in the mathematics department at St. George's, suggests that carefully timed rapid switches between multiple therapies can block cancer cells from evolving adaptive resistance.1 The research, published in Genetics volume 232, issue 2 in July 2026, indicates that two-drug treatment combinations may succeed only against relatively small tumors, while three or more sequential therapy switches could potentially eliminate larger cancers.1 Three clinical trials are currently underway testing the approach in soft tissue cancer, prostate cancer, and breast cancer patients.1
The interdisciplinary team behind the findings includes Srishti Patil, a student at the Indian Institute of Science Education and Research, Armaan Ahmed, an undergraduate at Johns Hopkins University, and Dr. Yannick Viossat from Paris Cité University.1
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