冷泉港实验室与斯克里普斯研究所的研究团队找到了一种重新激活万古霉素抗菌效能的途径。1他们利用一个名为pghi-4的小分子阻断细菌酶SagA，使这一传统抗生素能够重新有效杀死耐药性粪肠球菌（E. faecium）。1这一发现表明，通过改进现有药物的化学性质，可能成为应对超级细菌的重要策略，而不必开发全新的抗生素。1
研究人员采用多样性导向点击化学技术构建了包含150多种化合物的分子库，从而发现了pghi-4。1pghi-4最初在2020年由Moses实验室首次发现。1这项成果源于基础化学研究，而非直接针对新抗生素的药物搜索。1该研究已发表在《自然通讯》2026年刊物中。1
Researchers at Cold Spring Harbor Laboratory and the Scripps Research Institute have discovered a method to restore the effectiveness of vancomycin, a once-potent antibiotic that drug-resistant bacteria had rendered ineffective.1 By using a small molecule called pghi-4 to block the bacterial enzyme SagA, the team enabled vancomycin to kill antibiotic-resistant Enterococcus faecium once again.1
The pghi-4 compound was first identified by the Moses laboratory in 2020.1 Rather than pursuing the development of entirely new antibiotics, the research demonstrates that enhancing the chemical properties of existing drugs may represent a critical strategy in combating superbugs.1 Scientists constructed a molecular library containing more than 150 compounds using diversity-oriented click chemistry (DOC) technology to identify effective molecular partners for vancomycin.1 The breakthrough emerged from fundamental chemical research rather than from a direct search for novel antibiotics.1
The findings have been published in Nature Communications in 2026.1
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