一项最新研究表明，天然食物成分精胺可能帮助老年人在接种疫苗后产生更强的免疫保护。1由Max Delbrück分子医学中心和牛津大学NDORMS研究团队联合进行的试验中，研究人员给65岁以上成人在接种第三剂COVID-19疫苗后补充精胺，结果显示对初期免疫反应较差的人群效果最为显著。1该研究已发表在《衰老细胞》2026年第25卷第6期。1
试验共纳入40名65岁及以上健康成人，参与者在第三剂COVID-19疫苗接种后每天服用6毫克精胺或安慰剂，持续13周。1约四分之一的参与者即使在三剂疫苗接种后仍产生非常弱的抗体反应。1获得精胺补充的疫苗无反应者的多项免疫指标大幅改善，包括更高的SARS-CoV-2抗体水平和对多个病毒变异株的更强中和活性。1此外，精胺降低了与免疫衰老相关的标志物并增加了自噬作用。1研究未发现与治疗相关的不良反应。1
精胺存在于小麦胚芽、蘑菇、帕玛森芝士和切达芝士等食物中。1
A natural food component called spermidine has demonstrated potential to strengthen immune protection following vaccination in older adults, according to research findings.1 In a small-scale trial, researchers supplemented adults aged 65 and older with spermidine after receiving their third COVID-19 vaccine dose, with the most significant improvements observed in individuals who initially mounted poor immune responses, showing elevated antibody levels and enhanced neutralizing activity against multiple virus variants.1
The study, led by Dr. Katja Simon and Dr. Ghada Alsaleh and published in Aging Cell in 2026, involved 40 healthy adults aged 65 and over.1 Participants received either 6 milligrams of spermidine or placebo daily for 13 weeks following their third COVID-19 vaccination.1 Approximately one-quarter of participants showed very weak antibody responses despite receiving three vaccine doses.1 Those receiving spermidine supplementation experienced substantial improvements across multiple immune markers, including higher SARS-CoV-2 antibody levels and stronger neutralizing activity against several viral variants.1 The compound also reduced biomarkers associated with immune aging and increased autophagy, a cellular cleaning process.1 No adverse effects related to the treatment were reported.1
Spermidine occurs naturally in foods including wheat germ, mushrooms, Parmesan cheese, and cheddar cheese.1
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