东北大学研究人员发现，在练习后刺激迷走神经能够帮助小鼠形成更强的长期运动学习1。这项研究于2026年8月25日发表在《iScience》期刊上1，揭示了大脑在学习巩固期间的一个隐藏机制。
研究团队对小鼠进行了水平视动反应学习任务的训练1。关键在于迷走神经刺激的时机——松井教授表示，"关键点在于迷走神经刺激仅在训练后进行"1。单次迷走神经刺激会产生两阶段血管反应，表现为血量短暂下降随后延迟上升；重复刺激则产生节律性振荡1。到第5天时，血量振荡更大的小鼠显示出更好的学习效果1。
这一效应与大脑血管的节律性变化相关联，表明身体到大脑的信号可能有助于准备大脑进行持久改变1。研究主要作者陈俊宇指出，"我们的大脑可能比想象中更受身体的影响"1。
Researchers at Northeastern University have discovered that stimulating the vagus nerve after practice enables mice to form stronger long-term motor learning, revealing a previously hidden mechanism through which the brain consolidates new skills.1 The key finding is that vagus nerve stimulation (VNS) delivered only after training enhances learning performance, with the effect linked to rhythmic changes in cerebral blood volume.1 According to Professor Ko Matsui, "The key point is that VNS was delivered only after training."1
The study, published on August 25, 2026, in iScience (Volume 29, Issue 9, page 117413), involved mice performing a horizontal optokinetic response learning task.1 A single VNS application produced a two-phase vascular response characterized by an initial brief decrease in blood volume followed by a delayed increase, while repeated stimulation generated rhythmic oscillations.1 By day five, mice exhibiting larger blood volume oscillations demonstrated superior learning outcomes.1 Lead author Junyu Chen noted that "Our brains may be more strongly influenced by the body than we imagine," suggesting that signals from the body to the brain may help prepare neural tissue for lasting changes during the learning consolidation period.1
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