科罗拉多大学安施茨癌症中心的研究人员发现，高风险骨髓增生异常综合征(MDS)干细胞对NAD分子产生了异常的"能量成瘾"，严重依赖这一分子来维持其能量供应。1
研究表明，阻断NAMPT酶可以切断NAD的补充途径，从而选择性地削弱癌症干细胞，同时保护正常的健康血细胞。1高风险MDS干细胞对NAD的代谱依赖程度远高于正常血细胞。1由埃里克·皮特拉斯和克雷格·乔丹共同领导的研究团队发现，阻断该酶会导致癌症干细胞进入能量危机。1
该研究成果已发表于《血液癌症发现》期刊。1考虑到美国每年诊断出10000至20000例MDS患者，1研究人员计划进行针对NAMPT的临床药物研究。1
Researchers at the University of Colorado Anschutz Cancer Center have discovered that high-risk myelodysplastic syndrome (MDS) stem cells display an abnormal dependency on NAD molecules to maintain their energy supply 1. This metabolic vulnerability could provide a new therapeutic target for treating the disease.
The study, published in Blood Cancer Discovery, reveals that cancer stem cells rely far more heavily on NAD than normal blood cells do 1. By blocking the NAMPT enzyme, which is essential for NAD replenishment, scientists can selectively weaken cancer stem cells while protecting healthy blood cells 1. This approach forces cancer stem cells into an energy crisis, according to the research led by Eric M. Pietras and Craig T. Jordan 1.
The findings are particularly significant given the disease burden: approximately 10,000 to 20,000 MDS patients are diagnosed annually in the United States 1. The research team has already begun planning clinical drug studies targeting NAMPT to further investigate this therapeutic approach 1.
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