日本理化学研究所的研究团队发现了一种蛋白质，可以记录果蝇在幼虫阶段的饮食状况，并对其成年后的寿命产生深远影响1。这项研究由Fumiaki Obata领导，来自神户理化学研究所生物系统动力学研究中心，相关成果已发表在《自然》期刊1。
研究人员通过降低果蝇幼虫期的蛋白质摄入进行实验，将酵母浓度从8%降低至1%至2%，并在幼虫发育中期引入这种低蛋白饮食1。结果表明，早期营养限制对果蝇后续的健康状况和寿命造成了长期影响，解释了幼年时期的饮食为何能够影响数周、数月乃至数年后的生物体健康1。这种现象并非首次被观察到，早在1930年代就曾在水蚤和大鼠身上发现过类似的规律1。
Researchers at Japan's RIKEN Center for Biosystems Dynamics Research have identified a protein mechanism that records the dietary experiences of fruit fly larvae and influences their longevity in adulthood 1. Led by Fumiaki Obata, the team discovered that early nutritional restriction during the larval stage produces lasting health effects that persist into later life stages 1.
In their experiments, the researchers reduced protein availability by lowering yeast concentration from 8% to 1% or 2% during the middle larval period 1. This early dietary manipulation resulted in measurable impacts on the flies' subsequent lifespan, demonstrating that nutritional conditions experienced during development can shape health outcomes weeks, months, or potentially years later 1. The findings, published in Nature, provide a molecular explanation for how early-life diet becomes encoded in an organism's physiology 1. Similar dietary effects on longevity have been documented since the 1930s in water fleas and rats, but this research illuminates the specific biological mechanisms underlying the phenomenon 1.
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