俄勒冈大学的生物学家利用祖先序列重建技术复活了可追溯至1.6亿年前的哺乳动物抗菌肽1。这项研究成果已于2026年8月25日发表在《PLOS Biology》期刊第24卷第8期上1。
研究发现，某些重建的古代抗菌肽版本对耐药菌的效能超过了现代人类对应的肽类1。更令人瞩目的是，仅需单个氨基酸链突变就能使这些古代抗菌肽的效能大幅提升1。这些发现为开发新型抗菌治疗方案提供了重要启发。由马特·巴伯领导的研究团队得到了美国国立卫生研究院的资助1。巴伯表示："进化本质上是一个数十亿年的科学实验"1。
Biologists at the University of Oregon have resurrected antimicrobial peptides dating back 160 million years to the late Jurassic period using ancestral sequence reconstruction techniques.1 The research, published on August 25, 2026, in PLOS Biology Volume 24, Issue 8, Article e3003932, reveals that certain reconstructed ancient peptide versions demonstrate greater efficacy against antibiotic-resistant bacteria than their modern human counterparts.1
The study, led by doctoral student Titas Sil in Matt Barber's laboratory and funded by the National Institutes of Health, found that single amino acid mutations can dramatically enhance antimicrobial potency.1 According to Barber, the paper's corresponding author: "Evolution is essentially a billion-year scientific experiment."1 These findings suggest that examining ancient proteins may offer valuable insights for developing novel antimicrobial therapeutic approaches to combat resistant pathogens.
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