国际研究团队对来自五个国家的近500只家猫肿瘤样本进行了大规模遗传学分析，发现猫癌症与人类癌症存在显著的遗传相似性 1。其中最重要的发现是，超过50%的猫乳腺肿瘤中检出FBXW7基因突变，这与该基因突变在人类乳腺癌中的出现模式相似 1。FBXW7基因突变在人类乳腺癌患者中与更差的预后相关，猫的情况呈现出相同的关联 1。
该研究由来自圭尔夫大学、韦尔科姆桑格研究所、伯尔尼大学和安大略兽医学院的科研人员合作完成 1。研究显示，某些化疗药物对携带突变FBXW7基因的猫乳腺肿瘤更加有效 1，这为精准肿瘤学在猫和人类治疗中的应用开辟了新路径 1。该研究已于2026年9月26日发表在《科学》杂志第391卷第6787期第793页 1，同时研究团队公开发布了免费的遗传数据库供后续研究使用 1。该项目获得了EveryCat Health Foundation、CVS Group、Wellcome、加拿大自然科学与工程研究委员会和瑞士国家科学基金会等机构的资助 1。
An international research team has conducted a large-scale genetic analysis of tumors from nearly 500 house cats across five countries, revealing significant genetic similarities between feline and human cancers 1. The study, published in Science in 2026, found that mutations in the FBXW7 gene appear in over 50% of cat breast tumors at frequencies comparable to those observed in human breast cancer 1. This parallel genetic signature suggests that cats may serve as valuable models for understanding and developing cancer treatments applicable to both species.
Researchers discovered that the FBXW7 gene mutations in cats are linked to outcomes similar to those in humans, where such mutations correlate with poorer prognoses 1. Notably, certain chemotherapy drugs proved more effective against cat breast tumors carrying these FBXW7 mutations, suggesting a potential pathway for precision oncology approaches in both feline and human medicine 1. To facilitate further research, the team released a free genetic database of their findings 1. The work was supported by the EveryCat Health Foundation, CVS Group, Wellcome, Canada's Natural Sciences and Engineering Research Council, and the Swiss National Science Foundation 1.
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